Pike, KC;
Inskip, HM;
Robinson, S;
Lucas, JS;
Cooper, C;
Harvey, NC;
Godfrey, KM;
... Southampton Women's Survey Study Group; + view all
(2012)
Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes.
Thorax
, 67
(11)
pp. 950-956.
10.1136/thoraxjnl-2012-201888.
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Abstract
BACKGROUND: Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher vitamin D intake during pregnancy has been shown to lower the risk of childhood wheeze, yet a study of maternal late-pregnancy serum 25-hydroxyvitamin D suggested higher serum concentrations may be associated with increased childhood asthma. OBJECTIVE: To assess the relationship between mothers' serum 25-hydroxyvitamin D status and asthma and wheeze phenotypes in their children at age 6 years. Also to explore the relationship between maternal 25-hydroxyvitamin D status and objective measures of childhood atopy and lung function. METHODS: Serum 25-hydroxyvitamin D was measured at 34 weeks' gestation in the mothers of 860 children born at term. Wheeze was classified as either transient or persistent/late using questionnaire data collated from 6, 12, 24 and 36 months and 6 years. At 6 years spirometry was performed and atopic status was determined by skin prick testing, exhaled nitric oxide was measured in 451 children and bronchial hyperresponsiveness in 216 children. RESULTS: There were no significant associations between maternal late-pregnancy 25-hydroxyvitamin D status and either asthma or wheeze at age 6 years. Maternal vitamin D status was not associated with transient or persistent/late wheeze; no significant association was found between persistent/late wheeze when subdivided according to atopic status. No associations were found with skin sensitisation or lung function. CONCLUSIONS: This study provides no evidence that exposure to higher concentrations of 25-hydroxyvitamin D in maternal serum during late pregnancy increases the risk of childhood asthma, wheeze or atopy.
| Type: | Article |
|---|---|
| Title: | Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/thoraxjnl-2012-201888 |
| Publisher version: | http://dx.doi.org/10.1136/thoraxjnl-2012-201888 |
| Language: | English |
| Additional information: | This article has been accepted for publication in Thorax following peer review. The definitive copyedited, typeset version, Pike, KC; Inskip, HM; Robinson, S; Lucas, JS; Cooper, C; Harvey, NC; Godfrey, KM; (2012) Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. Thorax, 67 (11) pp. 950-956, is available online at: http://dx.doi.org/10.1136/thoraxjnl-2012-201888. |
| Keywords: | Adult, Algorithms, Asthma, Child, Child, Preschool, Dermatitis, Atopic, Diet, Female, Follow-Up Studies, Free Radical Scavengers, Great Britain, Health Surveys, Humans, Infant, Nitric Oxide, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Third, Respiratory Sounds, Risk Factors, Skin Tests, Spirometry, Surveys and Questionnaires, Vitamin D |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1461060 |
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