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Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes

Pike, KC; Inskip, HM; Robinson, S; Lucas, JS; Cooper, C; Harvey, NC; Godfrey, KM; ... Southampton Women's Survey Study Group; + view all (2012) Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. Thorax , 67 (11) pp. 950-956. 10.1136/thoraxjnl-2012-201888. Green open access

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Abstract

BACKGROUND: Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher vitamin D intake during pregnancy has been shown to lower the risk of childhood wheeze, yet a study of maternal late-pregnancy serum 25-hydroxyvitamin D suggested higher serum concentrations may be associated with increased childhood asthma. OBJECTIVE: To assess the relationship between mothers' serum 25-hydroxyvitamin D status and asthma and wheeze phenotypes in their children at age 6 years. Also to explore the relationship between maternal 25-hydroxyvitamin D status and objective measures of childhood atopy and lung function. METHODS: Serum 25-hydroxyvitamin D was measured at 34 weeks' gestation in the mothers of 860 children born at term. Wheeze was classified as either transient or persistent/late using questionnaire data collated from 6, 12, 24 and 36 months and 6 years. At 6 years spirometry was performed and atopic status was determined by skin prick testing, exhaled nitric oxide was measured in 451 children and bronchial hyperresponsiveness in 216 children. RESULTS: There were no significant associations between maternal late-pregnancy 25-hydroxyvitamin D status and either asthma or wheeze at age 6 years. Maternal vitamin D status was not associated with transient or persistent/late wheeze; no significant association was found between persistent/late wheeze when subdivided according to atopic status. No associations were found with skin sensitisation or lung function. CONCLUSIONS: This study provides no evidence that exposure to higher concentrations of 25-hydroxyvitamin D in maternal serum during late pregnancy increases the risk of childhood asthma, wheeze or atopy.

Type: Article
Title: Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/thoraxjnl-2012-201888
Publisher version: http://dx.doi.org/10.1136/thoraxjnl-2012-201888
Language: English
Additional information: This article has been accepted for publication in Thorax following peer review. The definitive copyedited, typeset version, Pike, KC; Inskip, HM; Robinson, S; Lucas, JS; Cooper, C; Harvey, NC; Godfrey, KM; (2012) Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes. Thorax, 67 (11) pp. 950-956, is available online at: http://dx.doi.org/10.1136/thoraxjnl-2012-201888.
Keywords: Adult, Algorithms, Asthma, Child, Child, Preschool, Dermatitis, Atopic, Diet, Female, Follow-Up Studies, Free Radical Scavengers, Great Britain, Health Surveys, Humans, Infant, Nitric Oxide, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Third, Respiratory Sounds, Risk Factors, Skin Tests, Spirometry, Surveys and Questionnaires, Vitamin D
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1461060
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