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Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable?

Selby, A; Clayton, B; Grundy, J; Pike, K; Drew, K; Raza, A; Kurukulaaratchy, R; ... Roberts, G; + view all (2010) Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable? Respiratory Research , 11 , Article 43. 10.1186/1465-9921-11-43. Green open access

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Abstract

BACKGROUND: Exhaled nitric oxide is a non-invasive marker of airway inflammation and a portable analyser, the NIOX MINO (Aerocrine AB, Solna, Sweden), is now available. This study aimed to assess the reproducibility of the NIOX MINO measurements across age, sex and lung function for both absolute and categorical exhaled nitric oxide values in two distinct groups of children and teenagers. METHODS: Paired exhaled nitric oxide readings were obtained from 494 teenagers, aged 16-18 years, enrolled in an unselected birth cohort and 65 young people, aged 6-17 years, with asthma enrolled in an interventional asthma management study. RESULTS: The birth cohort participants showed a high degree of variability between first and second exhaled nitric oxide readings (mean intra-participant difference 1.37 ppb, 95% limits of agreement -7.61 to 10.34 ppb), although there was very close agreement when values were categorised as low, normal, intermediate or high (kappa = 0.907, p < 0.001). Similar findings were seen in subgroup analyses by sex, lung function and asthma status. Similar findings were seen in the interventional study participants. CONCLUSIONS: The reproducibility of exhaled nitric oxide is poor for absolute values but acceptable when values are categorised as low, normal, intermediate or high in children and teenagers. One measurement is therefore sufficient when using categorical exhaled nitric oxide values to direct asthma management but a mean of at least two measurements is required for absolute values.

Type: Article
Title: Are exhaled nitric oxide measurements using the portable NIOX MINO repeatable?
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1465-9921-11-43
Publisher version: http://dx.doi.org/10.1186/1465-9921-11-43
Language: English
Additional information: Copyright © Selby et al. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Adolescent, Asthma, Breath Tests, Child, Clinical Trials as Topic, Cohort Studies, Equipment Design, Exhalation, Female, Great Britain, Humans, Male, Nitric Oxide, Observer Variation, Predictive Value of Tests, Reproducibility of Results, Respiratory Function Tests
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1461059
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