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Long term respiratory consequences of intrauterine growth restriction

Pike, K; Jane Pillow, J; Lucas, JS; (2012) Long term respiratory consequences of intrauterine growth restriction. Seminars in Fetal and Neonatal Medicine , 17 (2) pp. 92-98. 10.1016/j.siny.2012.01.003. Green open access

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Abstract

Epidemiological studies demonstrate that in-utero growth restriction and low birth weight are associated with impaired lung function and increased respiratory morbidity from infancy, throughout childhood and into adulthood. Chronic restriction of nutrients and/or oxygen during late pregnancy causes abnormalities in the airways and lungs of offspring, including smaller numbers of enlarged alveoli with thicker septal walls and basement membranes. The structural abnormalities and impaired lung function seen soon after birth persist or even progress with age. These changes are likely to cause lung symptomology through life and hasten lung aging.

Type: Article
Title: Long term respiratory consequences of intrauterine growth restriction
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.siny.2012.01.003
Publisher version: http://dx.doi.org/10.1016/j.siny.2012.01.003
Language: English
Additional information: © 2012. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0.
Keywords: Body Height, Chronic Disease, Female, Fetal Growth Retardation, Gestational Age, Humans, Incidence, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Lung Diseases, Organ Size, Pregnancy, Pulmonary Alveoli, Pulmonary Gas Exchange
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1461055
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