Pike, K;
Jane Pillow, J;
Lucas, JS;
(2012)
Long term respiratory consequences of intrauterine growth restriction.
Seminars in Fetal and Neonatal Medicine
, 17
(2)
pp. 92-98.
10.1016/j.siny.2012.01.003.
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Abstract
Epidemiological studies demonstrate that in-utero growth restriction and low birth weight are associated with impaired lung function and increased respiratory morbidity from infancy, throughout childhood and into adulthood. Chronic restriction of nutrients and/or oxygen during late pregnancy causes abnormalities in the airways and lungs of offspring, including smaller numbers of enlarged alveoli with thicker septal walls and basement membranes. The structural abnormalities and impaired lung function seen soon after birth persist or even progress with age. These changes are likely to cause lung symptomology through life and hasten lung aging.
| Type: | Article |
|---|---|
| Title: | Long term respiratory consequences of intrauterine growth restriction |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.siny.2012.01.003 |
| Publisher version: | http://dx.doi.org/10.1016/j.siny.2012.01.003 |
| Language: | English |
| Additional information: | © 2012. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. |
| Keywords: | Body Height, Chronic Disease, Female, Fetal Growth Retardation, Gestational Age, Humans, Incidence, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Lung Diseases, Organ Size, Pregnancy, Pulmonary Alveoli, Pulmonary Gas Exchange |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1461055 |
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