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Single-bacterium nanomechanics in biomedicine: unravelling the dynamics of bacterial cells.

Aguayo, S; Donos, N; Spratt, D; Bozec, L; (2015) Single-bacterium nanomechanics in biomedicine: unravelling the dynamics of bacterial cells. Nanotechnology , 26 (6) , Article 062001. 10.1088/0957-4484/26/6/062001. Green open access

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Abstract

The use of the atomic force microscope (AFM) in microbiology has progressed significantly throughout the years since its first application as a high-resolution imaging instrument. Modern AFM setups are capable of characterizing the nanomechanical behaviour of bacterial cells at both the cellular and molecular levels, where elastic properties and adhesion forces of single bacterium cells can be examined under different experimental conditions. Considering that bacterial and biofilm-mediated infections continue to challenge the biomedical field, it is important to understand the biophysical events leading towards bacterial adhesion and colonization on both biological and non-biological substrates. The purpose of this review is to present the latest findings concerning the field of single-bacterium nanomechanics, and discuss future trends and applications of nanoindentation and single-cell force spectroscopy techniques in biomedicine.

Type: Article
Title: Single-bacterium nanomechanics in biomedicine: unravelling the dynamics of bacterial cells.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/0957-4484/26/6/062001
Publisher version: http://dx.doi.org/10.1088/0957-4484/26/6/062001
Language: English
Additional information: Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1460913
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