Hossin, B;
(2015)
The Rational Design of an Antifungal Nail Lacquer Using the Hansen Solubility Parameter Concept.
Doctoral thesis , UCL (University College London).
Abstract
Introduction- Lacquers are ideal as topical drug carriers for the treatment of nail fungal infections. In this work, the Hansen Solubility Parameter (HSP) concept, which reflects the notion that ‘like’ seeks ‘like’, was investigated as a potentially useful tool in the rational formulation of an antifungal nail lacquer. This was done by evaluating the influence of HSPs, if any, on various steps of the lacquer development programme, including: (i) maximum drug loading in the lacquers, (ii) lacquer water resistivity and adhesion, (iii) drug release and ungual permeation from the films. Methods- HSPs of the antifungal drugs (i.e. amorolfine, terbinafine and ciclopirox), twelve polymers (as lacquer film-formers) the human nail and its models (bovine hoof and high density polyethylene(HDPE) sheets) were determined. Polymers were classified as ‘good’ or ‘bad’ depending on their HSPs and lacquers consisting of these polymers were then selected to test the potential usefulness of the HSP concept. Subsequently, the drugs’ saturation solubility in the lacquer films, adhesive strengths and water resistivity were determined. Finally, drug release and ungual drug permeation from the lacquer films were determined. Results- HSPs indicated that both the nail and hoof have a high affinity for polar and hydrogen bonding molecules, and that the antifungals have a high affinity for the nail. Moreover, the closer the HSPs of the drug and the polymer (i.e. ‘good’ polymers), the higher the drugs’ saturation concentrations achieved in the lacquer films. Smaller affinities between the drugs and the polymers (i.e. ‘bad’ polymers) allowed higher ungual drug permeation. However, HSPs could not predict the lacquers’ adhesive strengths or drug release Conclusion – HSP is a useful tool in the rational design of an antifungal nail lacquer.
| Type: | Thesis (Doctoral) |
|---|---|
| Title: | The Rational Design of an Antifungal Nail Lacquer Using the Hansen Solubility Parameter Concept |
| Language: | English |
| UCL classification: | UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1460876 |
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