Pinto, G;
Alhaiek, AAM;
Godovac-Zimmermann, J;
(2015)
Proteomics reveals the importance of the dynamic redistribution of the subcellular location of proteins in breast cancer cells.
Expert Review of Proteomics
, 12
(1)
pp. 61-74.
10.1586/14789450.2015.1002474.
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Abstract
At the molecular level, living cells are enormously complicated complex adaptive systems in which intertwined genomic, transcriptomic, proteomic and metabolic networks all play a crucial role. At the same time, cells are spatially heterogeneous systems in which subcellular compartmentalization of different functions is ubiquitous and requires efficient cross-compartmental communication. Dynamic redistribution of multitudinous proteins to different subcellular locations in response to cellular functional state is increasingly recognized as a crucial characteristic of cellular function that seems to be at least as important as overall changes in protein abundance. Characterization of the subcellular spatial dynamics of protein distribution is a major challenge for proteomics and recent results with MCF7 breast cancer cells suggest that this may be of particular importance for cancer cells.
| Type: | Article |
|---|---|
| Title: | Proteomics reveals the importance of the dynamic redistribution of the subcellular location of proteins in breast cancer cells |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1586/14789450.2015.1002474 |
| Publisher version: | http://dx.doi.org/10.1586/14789450.2015.1002474 |
| Language: | English |
| Additional information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Proteomics on 16 January 2015, available online: http://www.tandfonline.com/10.1586/14789450.2015.1002474. |
| Keywords: | breast cancer, cytoplasm, estrogen receptor, mass spectrometry, MCF7 cells, nucleus, protein trafficking, quantitative proteomics, SILAC, subcellular protein location |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1460825 |
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