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Short-interval observational data to inform clinical trial design in Huntington's disease

Hobbs, NZ; Farmer, RE; Rees, EM; Cole, JH; Haider, S; Malone, IB; Sprengelmeyer, R; ... Tabrizi, SJ; + view all (2015) Short-interval observational data to inform clinical trial design in Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry 10.1136/jnnp-2014-309768. Green open access

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Abstract

To evaluate candidate outcomes for disease-modifying trials in Huntington's disease (HD) over 6-month, 9-month and 15-month intervals, across multiple domains. To present guidelines on rapid efficacy readouts for disease-modifying trials.

Type: Article
Title: Short-interval observational data to inform clinical trial design in Huntington's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2014-309768
Publisher version: http://dx.doi.org/10.1136/jnnp-2014-309768
Language: English
Additional information: This article has been accepted for publication in Journal of Neurology, Neurosurgery and Psychiatry following peer review. The definitive copyedited, typeset version [Hobbs, NZ; Farmer, RE; Rees, EM; Cole, JH; Haider, S; Malone, IB; Sprengelmeyer, R; Johnson, H; Mueller, HP; Sussmuth, SD; Roos, RA; Durr, A; Frost, C; Scahill, RI; Landwehrmeyer, B; Tabrizi, SJ;(2015) Short-interval observational data to inform clinical trial design in Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry] is available online at: http://dx.doi.org/10.1136/jnnp-2014-309768
Keywords: HUNTINGTON'S, MRI
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > IoN Central Administration
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1460746
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