Hobbs, NZ;
Farmer, RE;
Rees, EM;
Cole, JH;
Haider, S;
Malone, IB;
Sprengelmeyer, R;
... Tabrizi, SJ; + view all
(2015)
Short-interval observational data to inform clinical trial design in Huntington's disease.
Journal of Neurology, Neurosurgery and Psychiatry
10.1136/jnnp-2014-309768.
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Abstract
To evaluate candidate outcomes for disease-modifying trials in Huntington's disease (HD) over 6-month, 9-month and 15-month intervals, across multiple domains. To present guidelines on rapid efficacy readouts for disease-modifying trials.
| Type: | Article |
|---|---|
| Title: | Short-interval observational data to inform clinical trial design in Huntington's disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/jnnp-2014-309768 |
| Publisher version: | http://dx.doi.org/10.1136/jnnp-2014-309768 |
| Language: | English |
| Additional information: | This article has been accepted for publication in Journal of Neurology, Neurosurgery and Psychiatry following peer review. The definitive copyedited, typeset version [Hobbs, NZ; Farmer, RE; Rees, EM; Cole, JH; Haider, S; Malone, IB; Sprengelmeyer, R; Johnson, H; Mueller, HP; Sussmuth, SD; Roos, RA; Durr, A; Frost, C; Scahill, RI; Landwehrmeyer, B; Tabrizi, SJ;(2015) Short-interval observational data to inform clinical trial design in Huntington's disease. Journal of Neurology, Neurosurgery and Psychiatry] is available online at: http://dx.doi.org/10.1136/jnnp-2014-309768 |
| Keywords: | HUNTINGTON'S, MRI |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > IoN Central Administration UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1460746 |
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