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OPA1 in Cardiovascular Health and Disease.

Burke, N; Hall, AR; Hausenloy, DJ; (2015) OPA1 in Cardiovascular Health and Disease. Curr Drug Targets , 16 (8) pp. 912-920. 10.2174/1389450116666150102113648. Green open access

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Abstract

Mitochondria are known to play crucial roles in normal cellular physiology and in more recent years they have been implicated in a wide range of pathologies. Central to both these roles is their ability to alter their shape interchangeably between two different morphologies: an elongated interconnected network and a fragmented discrete phenotype - processes which are under the regulation of the mitochondrial fusion and fission proteins, respectively. In this review article, we focus on the mitochondrial fusion protein optic atrophy protein 1 (OPA1) in cardiovascular health and disease and we explore its role as a potential therapeutic target for treating cardiovascular and metabolic disease.

Type: Article
Title: OPA1 in Cardiovascular Health and Disease.
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/1389450116666150102113648
Publisher version: http://dx.doi.org/ 10.2174/13894501166661501021136...
Additional information: Copyright © 2015 Bentham Science. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1389450116666150102113648 - See more at: http://beta.eurekaselect.com/node/590/current-drug-targets/ifa#sthash.LSUX4SlL.dpuf
Keywords: Cardiovascular disease, fission, fusion, mitochondrial morphology, OPA1.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Hatter Cardiovascular Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/1460671
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