Burke, N;
Hall, AR;
Hausenloy, DJ;
(2015)
OPA1 in Cardiovascular Health and Disease.
Curr Drug Targets
, 16
(8)
pp. 912-920.
10.2174/1389450116666150102113648.
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Abstract
Mitochondria are known to play crucial roles in normal cellular physiology and in more recent years they have been implicated in a wide range of pathologies. Central to both these roles is their ability to alter their shape interchangeably between two different morphologies: an elongated interconnected network and a fragmented discrete phenotype - processes which are under the regulation of the mitochondrial fusion and fission proteins, respectively. In this review article, we focus on the mitochondrial fusion protein optic atrophy protein 1 (OPA1) in cardiovascular health and disease and we explore its role as a potential therapeutic target for treating cardiovascular and metabolic disease.
| Type: | Article |
|---|---|
| Title: | OPA1 in Cardiovascular Health and Disease. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2174/1389450116666150102113648 |
| Publisher version: | http://dx.doi.org/ 10.2174/13894501166661501021136... |
| Additional information: | Copyright © 2015 Bentham Science. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/1389450116666150102113648 - See more at: http://beta.eurekaselect.com/node/590/current-drug-targets/ifa#sthash.LSUX4SlL.dpuf |
| Keywords: | Cardiovascular disease, fission, fusion, mitochondrial morphology, OPA1. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1460671 |
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