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Effects of donor/recipient human leukocyte antigen mismatch on human cytomegalovirus replication following liver transplantation

Aldridge, RW; Mattes, FM; Rolando, N; Rolles, K; Smith, C; Shirling, G; Atkinson, C; ... Griffiths, PD; + view all (2015) Effects of donor/recipient human leukocyte antigen mismatch on human cytomegalovirus replication following liver transplantation. Transplant Infectious Disease , 17 (1) 25 - 32. 10.1111/tid.12325. Green open access

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Abstract

Natural immunity against cytomegalovirus (CMV) can control virus replication after solid organ transplantation; however, it is not known which components of the adaptive immune system mediate this protection. We investigated whether this protection requires human leukocyte antigen (HLA) matching between donor and recipient by exploiting the fact that, unlike transplantation of other solid organs, liver transplantation does not require HLA matching, but some donor and recipient pairs may nevertheless be matched by chance.

Type: Article
Title: Effects of donor/recipient human leukocyte antigen mismatch on human cytomegalovirus replication following liver transplantation
Location: Denmark
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/tid.12325
Publisher version: http://dx.doi.org/10.1111/tid.12325
Language: English
Additional information: © 2015 The Authors. Transplant Infectious Disease Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: HLA match, cytomegalovirus, immunity, liver transplant
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
URI: https://discovery.ucl.ac.uk/id/eprint/1460623
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