Song, X;
Tabak, AG;
Zethelius, B;
Yudkin, JS;
Soederberg, S;
Laatikainen, T;
Stehouwer, CDA;
... Qiao, Q; + view all
(2014)
Obesity attenuates gender differences in cardiovascular mortality.
Cardiovascular Diabetology
, 13
, Article 144. 10.1186/s12933-014-0144-5.
Preview |
Text (Published article)
Song_Obesity_attenuates_gender_differences.pdf - Published Version Download (276kB) | Preview |
Preview |
Text (Supplementary information)
Song_Obesity_attenuates_gender_differences_Supplementary.pdf Download (598kB) | Preview |
Abstract
BACKGROUND: To estimate cardiovascular disease (CVD) mortality in relation to obesity and gender. METHODS: Data from 11 prospective cohorts from four European countries including 23 629 men and 21 965 women, aged 24 to 99 years, with a median follow-up of 7.9 years were analyzed. Hazards ratios (HR) for CVD mortality in relation to baseline body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were estimated using Cox proportional hazards models with age as the timescale. RESULTS: Men had higher CVD mortality than women in all four BMI categories (<25.0, 25.0-29.9, 30.0-34.9 and ≥35.0 kg/m2). Compared with the lowest BMI category in women, multivariable adjusted HRs (95% confidence intervals) for higher BMI categories are 1.0 (0.8-1.4), 1.6 (1.1-2.1) and 2.8 (2.0-3.8) in women and 2.8 (2.2-3.6), 3.1 (2.5-3.9), 3.8 (2.9-4.9) and 5.4 (3.8-7.7) in men, respectively. Similar findings were observed for abdominal obesity defined by WC, WHR or WHtR. The gender difference was slightly smaller in obese than in non-obese individuals; but the interaction was statistically significant only between gender and WC (p = 0.02), and WHtR (p = 0.01). None of the interaction terms was significant among non-diabetic individuals. CONCLUSIONS: Men had higher CVD mortality than women across categories of anthropometric measures of obesity. The gender difference was attenuated in obese individuals, which warrants further investigation.
| Type: | Article |
|---|---|
| Title: | Obesity attenuates gender differences in cardiovascular mortality |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s12933-014-0144-5 |
| Publisher version: | http://dx.doi.org/10.1186/s12933-014-0144-5 |
| Language: | English |
| Additional information: | Copyright © Song et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| Keywords: | Obesity; Gender; Cardiovascular disease mortality |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1460282 |
Archive Staff Only
 |
View Item |
