Tillo, M;
Erskine, L;
Cariboni, A;
Fantin, A;
Joyce, A;
Denti, L;
Ruhrberg, C;
(2015)
VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain.
Development
, 142
(2)
314 - 319.
10.1242/dev.115998.
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Abstract
The vascular endothelial growth factor (VEGFA, VEGF) regulates neurovascular patterning. Alternative splicing of the Vegfa gene gives rise to three major isoforms termed VEGF121, VEGF165 and VEGF189. VEGF165 binds the transmembrane protein neuropilin 1 (NRP1) and promotes the migration, survival and axon guidance of subsets of neurons, whereas VEGF121 cannot activate NRP1-dependent neuronal responses. By contrast, the role of VEGF189 in NRP1-mediated signalling pathways has not yet been examined. Here, we have combined expression studies and in situ ligand-binding assays with the analysis of genetically altered mice and in vitro models to demonstrate that VEGF189 can bind NRP1 and promote NRP1-dependent neuronal responses.
| Type: | Article |
|---|---|
| Title: | VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain. |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1242/dev.115998 |
| Publisher version: | http://dx.doi.org/10.1242/dev.115998 |
| Language: | English |
| Additional information: | © 2015. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
| Keywords: | Mouse, Neuron, Neuropilin, VEGF189, Vascular endothelial growth factor (VEGF), Animals, Brain, In Situ Hybridization, Mice, Models, Neurological, Neurons, Neuropilin-1, Oligonucleotides, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA, Vascular Endothelial Growth Factor A |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1459677 |
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