Buanz, AB;
Belaunde, CC;
Soutari, N;
Tuleu, C;
Gul, MO;
Gaisford, S;
(2015)
Ink-jet printing versus solvent casting to prepare oral films: Effect on mechanical properties and physical stability.
International Journal of Pharmaceutics
, 494
(2)
pp. 611-618.
10.1016/j.ijpharm.2014.12.032.
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Abstract
The aim of this work was to compare and contrast the mechanical properties and physical stabilities of oral films prepared with either thermal ink-jet printing (TIJP) or solvent casting (SC). Clonidine hydrochloride was selected as a model drug because of its low therapeutic dose and films were prepared using cellulose polymers. Mechanical testing showed that the printed films had Young's moduli and tensile strength values similar to the free film, while casted films were significantly more brittle. The drug also appeared to crystallize out of casted films during stress testing whereas printed films remained unchanged. The dissolution behavior of printed and cast films were similar, because of the rapid disintegration of the polymer. The conclusion is that printing resulted in a better film than casting because the drug resided on the film, rather than in the film where it could exert a plasticizing effect.
| Type: | Article |
|---|---|
| Title: | Ink-jet printing versus solvent casting to prepare oral films: Effect on mechanical properties and physical stability. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijpharm.2014.12.032 |
| Publisher version: | http://dx.doi.org/10.1016/j.ijpharm.2014.12.032 |
| Language: | English |
| Additional information: | C Elsevier 2015. This article is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | Clonidine, Critical humidity, Dynamic mechanical analysis, Oral films, Thermal ink-jet printing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1459257 |
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