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Purified IgG from patients with obstetric but not IgG from non-obstetric antiphospholipid syndrome inhibit trophoblast invasion

Poulton, K; Ripoll, VM; Pericleous, C; Meroni, PL; Gerosa, M; Ioannou, Y; Rahman, A; (2015) Purified IgG from patients with obstetric but not IgG from non-obstetric antiphospholipid syndrome inhibit trophoblast invasion. American Journal of Reproductive Immunology , 73 (5) pp. 390-401. 10.1111/aji.12341. Green open access

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Abstract

Some patients with antiphospholipid syndrome (APS) suffer pregnancy morbidity (PM) but not vascular thrombosis (VT), whilst others suffer VT only. Therefore, we compared the effects of IgG from VT+/PM- and VT-/PM+ subjects on human first-trimester trophoblast (HTR8) cells.

Type: Article
Title: Purified IgG from patients with obstetric but not IgG from non-obstetric antiphospholipid syndrome inhibit trophoblast invasion
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/aji.12341
Publisher version: http://dx/doi.org/10.1111/aji.12341
Language: English
Additional information: © 2014 The Authors American Journal of Reproductive Immunology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Antiphospholipid, TLR4, obstetric, trophoblast
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1458301
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