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Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning.

Illangakoon, UE; Gill, H; Shearman, GC; Parhizkar, M; Mahalingam, S; Chatterton, NP; Williams, GR; (2014) Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning. Int J Pharm , 477 (1-2) 369 - 379. 10.1016/j.ijpharm.2014.10.036. Green open access

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Abstract

A series of polyvinylpyrrolidone fibers loaded with paracetamol (PCM) and caffeine (CAF) was fabricated by electrospinning and explored as potential oral fast-dissolving films. The fibers take the form of uniform cylinders with smooth surfaces, and contain the drugs in the amorphous form. Drug-polymer intermolecular interactions were evidenced by infrared spectroscopy and molecular modeling. The properties of the fiber mats were found to be highly appropriate for the preparation of oral fast dissolving films: their thickness is around 120-130 μm, and the pH after dissolution in deionized water lies in the range of 6.7-7.2. Except at the highest drug loading, the folding endurance of the fibers was found to be >20 times. A flavoring agent can easily be incorporated into the formulation. The fiber mats are all seen to disintegrate completely within 0.5s when added to simulated saliva solution. They release their drug cargo within around 150s in a dissolution test, and to undergo much more rapid dissolution than is seen for the pure drugs. The data reported herein clearly demonstrate that electrospun PCM/CAF fibers comprise excellent candidates for oral fast-dissolving films, which could be particularly useful for children and patients with swallowing difficulties.

Type: Article
Title: Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijpharm.2014.10.036
Publisher version: http://dx.doi.org/10.1016/j.ijpharm.2014.10.036
Language: English
Additional information: Copyright © 2014 Elsevier B.V. All rights reserved.
Keywords: Caffeine, Caffeine (PubChem CID: 2519), Electrospinning, Fast-dissolving drug delivery system, Nanofiber, Paracetamol, Paracetamol (PubChem CID: 1983), Polyvinylpyrrolidone (PubChem CID: 6917)
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1457592
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