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Prospective regenerative medicine therapies for obstetric trauma-induced fecal incontinence.

Parmar, N; Kumar, L; Emmanuel, A; Day, RM; (2014) Prospective regenerative medicine therapies for obstetric trauma-induced fecal incontinence. Regenerative Medicine , 9 (6) 831 - 840. 10.2217/rme.14.56. Green open access

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Abstract

Fecal incontinence is a major public health issue that has yet to be adequately addressed. Obstetric trauma and injury to the anal sphincter muscles are the most common cause of fecal incontinence. New therapies are emerging aimed at repair or regeneration of sphincter muscle and restoration of continence. While regenerative medicine offers an attractive option for fecal incontinence there are currently no validated techniques using this approach. Although many challenges are yet to be resolved, the advent of regenerative medicine is likely to offer disruptive technologies to treat and possibly prevent the onset of this devastating condition. This article provides a review on regenerative medicine approaches for treating fecal incontinence and a critique of the current landscape in this area.

Type: Article
Title: Prospective regenerative medicine therapies for obstetric trauma-induced fecal incontinence.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/rme.14.56
Publisher version: http://dx.doi.org/10.2217/rme.14.56
Language: English
Additional information: This work is licensed under the Creative Commons Attribution-NonCommercial 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
Keywords: biomaterials, cell therapy, fecal incontinence, muscle, obstetric trauma, regenerative medicine, tissue engineering
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/1457368
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