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Ongoing developments in sporadic inclusion body myositis.

Machado, PM; Ahmed, M; Brady, S; Gang, Q; Healy, E; Morrow, JM; Wallace, AC; ... Hanna, MG; + view all (2014) Ongoing developments in sporadic inclusion body myositis. Curr Rheumatol Rep , 16 (12) , Article 477. 10.1007/s11926-014-0477-9. Green open access

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Abstract

Sporadic inclusion body myositis (IBM) is an acquired muscle disorder associated with ageing, for which there is no effective treatment. Ongoing developments include: genetic studies that may provide insights regarding the pathogenesis of IBM, improved histopathological markers, the description of a new IBM autoantibody, scrutiny of the diagnostic utility of clinical features and biomarkers, the refinement of diagnostic criteria, the emerging use of MRI as a diagnostic and monitoring tool, and new pathogenic insights that have led to novel therapeutic approaches being trialled for IBM, including treatments with the objective of restoring protein homeostasis and myostatin blockers. The effect of exercise in IBM continues to be investigated. However, despite these ongoing developments, the aetiopathogenesis of IBM remains uncertain. A translational and multidisciplinary collaborative approach is critical to improve the diagnosis, treatment, and care of patients with IBM.

Type: Article
Title: Ongoing developments in sporadic inclusion body myositis.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11926-014-0477-9
Publisher version: http://dx.doi.org/10.1007/s11926-014-0477-9
Language: English
Additional information: © The Author(s) 2014. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1457180
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