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Genetic background and light-dependent progression of photoreceptor cell degeneration in prominin-1 knockout mice.

Dellett, M; Sasai, N; Nishide, K; Becker, S; Papadaki, V; Limb, GA; Moore, AT; ... Ohnuma, S; + view all (2015) Genetic background and light-dependent progression of photoreceptor cell degeneration in prominin-1 knockout mice. Investigative Ophthalmology & Visual Science , 56 (1) 164 - 176. 10.1167/iovs.14-15479. Green open access

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Abstract

Mutations in the Prominin-1 (Prom1) gene are known to cause retinitis pigmentosa and Stargardt disease, both of which are associated with progressive photoreceptor cell death. There are no effective therapies for either disorder. The aim of this study was to investigate the mechanism of the retinal degeneration in Prom1-deficient mouse models.

Type: Article
Title: Genetic background and light-dependent progression of photoreceptor cell degeneration in prominin-1 knockout mice.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1167/iovs.14-15479
Publisher version: http://dx.doi.org/10.1167/iovs.14-15479
Language: English
Keywords: Prominin-1, Stargardt disease, fenretinide, light, modifier gene, photoreceptor degeneration, retinitis pigmentosa
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1457168
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