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Seven challenges for modelling indirect transmission: Vector-borne diseases, macroparasites and neglected tropical diseases

Hollingsworth, TD; Pulliam, JRC; Funk, S; Truscott, JE; Isham, V; Lloyd, AL; (2015) Seven challenges for modelling indirect transmission: Vector-borne diseases, macroparasites and neglected tropical diseases. Epidemics , 10 pp. 16-20. 10.1016/j.epidem.2014.08.007. Green open access

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Abstract

Many of the challenges which face modellers of directly transmitted pathogens also arise when modelling the epidemiology of pathogens with indirect transmission – whether through environmental stages, vectors, intermediate hosts or multiple hosts. In particular, understanding the roles of different hosts, how to measure contact and infection patterns, heterogeneities in contact rates, and the dynamics close to elimination are all relevant challenges, regardless of the mode of transmission. However, there remain a number of challenges that are specific and unique to modelling vector-borne diseases and macroparasites. Moreover, many of the neglected tropical diseases which are currently targeted for control and elimination are vector-borne, macroparasitic, or both, and so this article includes challenges which will assist in accelerating the control of these high-burden diseases. Here, we discuss the challenges of indirect measures of infection in humans, whether through vectors or transmission life stages and in estimating the contribution of different host groups to transmission. We also discuss the issues of “evolution-proof” interventions against vector-borne disease.

Type: Article
Title: Seven challenges for modelling indirect transmission: Vector-borne diseases, macroparasites and neglected tropical diseases
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.epidem.2014.08.007
Publisher version: http://dx.doi.org/10.1016/j.epidem.2014.08.007
Language: English
Additional information: © 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license(http://creativecommons.org/licenses/by/3.0/).
Keywords: Vector-borne disease; Macroparasites; Neglected tropical diseases; Helminths; Vectors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Statistical Science
URI: https://discovery.ucl.ac.uk/id/eprint/1457123
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