Robinson, OJ;
Krimsky, M;
Lieberman, L;
Allen, P;
Vytal, K;
Grillon, C;
(2014)
The dorsal medial prefrontal (anterior cingulate) cortex–amygdala aversive amplification circuit in unmedicated generalised and social anxiety disorders: an observational study.
Lancet Psychiatry
, 1
(4)
294 - 302.
10.1016/S2215-0366(14)70305-0.
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Abstract
We have delineated, across four prior studies, the role of positive dorsal medial prefrontal/anterior cingulate cortex (dmPFC/ACC)-amygdala circuit coupling during aversive processing in healthy individuals under stress. This translational circuit, termed the 'aversive amplification circuit', is thought to drive adaptive, harm-avoidant behavior in threatening environments. Here, in a natural progression of this prior work, we confirm that this circuit also plays a role in the pathological manifestation of anxiety disorders.
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