Pillidge, K;
Porter, AJ;
Vasili, T;
Heal, DJ;
Stanford, SC;
(2014)
Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor 'knockout' mice.
Pharmacol Biochem Behav
, 127
56 - 61.
10.1016/j.pbb.2014.10.008.
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Abstract
Mice with functional ablation of the neurokinin-1 receptor gene (NK1R(-/-)) display behavioural abnormalities which resemble the hyperactivity, inattention and impulsivity seen in Attention Deficit Hyperactivity Disorder (ADHD). Here, we investigated whether the established ADHD treatment, atomoxetine, alleviates these abnormalities when tested in the light/dark exploration box (LDEB) and 5-Choice Serial Reaction-Time Task (5-CSRTT).
| Type: | Article |
|---|---|
| Title: | Atomoxetine reduces hyperactive/impulsive behaviours in neurokinin-1 receptor 'knockout' mice. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.pbb.2014.10.008 |
| Publisher version: | http://dx.doi.org/10.1016/j.pbb.2014.10.008 |
| Language: | English |
| Additional information: | © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
| Keywords: | 5-Choice Serial Reaction-Time Task, Atomoxetine, Attention Deficit Hyperactivity Disorder, Hyperactivity, Impulsivity, NK1R(−/−) ‘knockout’ mouse |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1456508 |
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