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Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study.

Davies, BM; Rikabi, S; French, A; Pinedo-Villanueva, R; Morrey, ME; Wartolowska, K; Judge, A; ... Brindley, DA; + view all (2014) Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study. J Tissue Eng , 5 -. 10.1177/2041731414551764. Green open access

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Abstract

There has been a large increase in basic science activity in cell therapy and a growing portfolio of cell therapy trials. However, the number of industry products available for widespread clinical use does not match this magnitude of activity. We hypothesize that the paucity of engagement with the clinical community is a key contributor to the lack of commercially successful cell therapy products. To investigate this, we launched a pilot study to survey clinicians from five specialities and to determine what they believe to be the most significant barriers to cellular therapy clinical development and adoption. Our study shows that the main concerns among this group are cost-effectiveness, efficacy, reimbursement, and regulation. Addressing these concerns can best be achieved by ensuring that future clinical trials are conducted to adequately answer the questions of both regulators and the broader clinical community.

Type: Article
Title: Quantitative assessment of barriers to the clinical development and adoption of cellular therapies: A pilot study.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/2041731414551764
Publisher version: http://dx.doi.org/10.1177/2041731414551764
Language: English
Additional information: Copyright © The Author(s) 2014. Creative Commons CC-BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm)
Keywords: Cell- and tissue-based therapy, regenerative medicine, stem cells, tissue engineering, translational medical research
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
URI: https://discovery.ucl.ac.uk/id/eprint/1456316
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