UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Genetic susceptibility testing and readiness to control weight: results from a randomized controlled trial

Meisel, S; Beeken, RJ; van Jaarsveld, CHM; Wardle, J; (2015) Genetic susceptibility testing and readiness to control weight: results from a randomized controlled trial. Obesity , 23 (2) pp. 305-312. 10.1002/oby.20958. Green open access

[thumbnail of FTOTrialSubmit_Final_UCLDepository.pdf] Text
FTOTrialSubmit_Final_UCLDepository.pdf
Access restricted to UCL open access staff
Available under License : See the attached licence file.

Download (622kB)
[thumbnail of Article] Text (Article)
oby20958.pdf
Available under License : See the attached licence file.

Download (297kB)

Abstract

Objective: To test the hypothesis that adding obesity gene feedback (FTO) to simple weight control advice at a life stage with raised risk of weight gain increases readiness to control weight. Methods: Individually-randomized controlled trial comparing the effect of: i) simple weight control advice plus FTO feedback (FA) and ii) simple weight control advice only (AO), on readiness to engage with weight control. Differences in stage of change by genotype, and differential weight control behaviors, were secondary outcomes. Results: Of 1016 participants randomized, only 279 completed follow-up; yielding 90% power to detect a small effect for readiness to control weight. As predicted, FA participants were more likely to be in the contemplation stage than AO participants (p=0.023). Participants receiving higher-risk genetic results were at a higher stage of change than controls (p=0.003), with a trend towards a higher stage of change than those getting lower-risk results (p=0.052). Lower-risk results did not decrease weight control intentions compared with controls (p=0.55). There were no group differences in adherence to recommended weight control behaviors (p=0.85). Conclusion: Adding FTO feedback to weight control advice enhanced readiness to control weight, without evidence for genetic determinism, but had no more effect on behavior than weight control advice alone.

Type: Article
Title: Genetic susceptibility testing and readiness to control weight: results from a randomized controlled trial
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/oby.20958
Publisher version: http://dx.doi.org/10.1002/oby.20958
Language: English
Additional information: © 2014 The Authors Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS) This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
URI: https://discovery.ucl.ac.uk/id/eprint/1454088
Downloads since deposit
147Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item