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A dysglycaemic effect of statins in diabetes: relevance to clinical practice?

Swerdlow, DI; Sattar, N; (2014) A dysglycaemic effect of statins in diabetes: relevance to clinical practice? Diabetologia , 57 (12) 2433 - 2435. 10.1007/s00125-014-3409-3. Green open access

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Abstract

In this issue of the journal, Erqou and colleagues (DOI 10.1007/s00125-014-3374-x ) report, in a systematic review and meta-analysis of randomised trials, a very modest (1.3 mmol/mol or 0.12%) albeit significant increase in HbA1c in patients with diabetes treated with statins, compared with control. Here, we discuss the clinical relevance of the findings. Given the overwhelming benefit of statins on cardiovascular outcomes in diabetes, current guidelines recommending statins for primary prevention in type 2 diabetes should not change, and any effect on microvascular risk is likely to be minimal. Of course, all patients recommended for statin treatment, whether they have diabetes or not, should now be warned of a slight potential for dysglycaemia on starting statins, but at the same time they should be told that very modest lifestyle improvement will help offset this dysglycaemia risk. Finally, we remind colleagues that nearly all drugs have side effects and we should not be surprised by this statin-dysglycaemia effect, which can be easily managed.

Type: Article
Title: A dysglycaemic effect of statins in diabetes: relevance to clinical practice?
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00125-014-3409-3
Publisher version: http://dx.doi.org/10.1007/s00125-014-3409-3
Language: English
Additional information: © The Author(s) 2014 This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: https://discovery.ucl.ac.uk/id/eprint/1453552
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