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Mitochondrial dynamics in astrocytes.

Stephen, TL; Gupta-Agarwal, S; Kittler, JT; (2014) Mitochondrial dynamics in astrocytes. Biochem Soc Trans , 42 (5) 1302 - 1310. 10.1042/BST20140195. Green open access

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Abstract

Astrocytes exhibit cellular excitability through variations in their intracellular calcium (Ca(2+)) levels in response to synaptic activity. Astrocyte Ca(2+) elevations can trigger the release of neuroactive substances that can modulate synaptic transmission and plasticity, hence promoting bidirectional communication with neurons. Intracellular Ca(2+) dynamics can be regulated by several proteins located in the plasma membrane, within the cytosol and by intracellular organelles such as mitochondria. Spatial dynamics and strategic positioning of mitochondria are important for matching local energy provision and Ca(2+) buffering requirements to the demands of neuronal signalling. Although relatively unresolved in astrocytes, further understanding the role of mitochondria in astrocytes may reveal more about the complex bidirectional relationship between astrocytes and neurons in health and disease. In the present review, we discuss some recent insights regarding mitochondrial function, transport and turnover in astrocytes and highlight some important questions that remain to be answered.

Type: Article
Title: Mitochondrial dynamics in astrocytes.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/BST20140195
Publisher version: http://dx.doi.org/10.1042/BST20140195
Language: English
Additional information: © 2014 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1453158
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