Bates, R;
Blyuss, O;
Alsaedi, A;
Zaikin, A;
(2015)
Effect of noise in intelligent cellular decision making.
PLOS ONE
, 10
(5)
, Article e0125079. 10.1371/journal.pone.0125079.
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Abstract
Similar to intelligent multicellular neural networks controlling human brains, even single cells surprisingly are able to make intelligent decisions to classify several external stimuli or to associate them. This happens because of the fact that gene regulatory networks can perform as perceptrons, simple intelligent schemes known from studies on Artificial Intelligence. We study the role of genetic noise in intelligent decision making at the genetic level and show that noise can play a constructive role helping cells to make a proper decision. We show this using the example of a simple genetic classifier able to classify two external stimuli.
| Type: | Article |
|---|---|
| Title: | Effect of noise in intelligent cellular decision making |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0125079 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0125079 |
| Additional information: | © 2015 Bates et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
| Keywords: | q-bio.MN, q-bio.MN |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Womens Cancer |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1453126 |
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