UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Delayed auditory feedback simulates features of nonfluent primary progressive aphasia.

Maruta, C; Makhmood, S; Downey, LE; Golden, HL; Fletcher, PD; Witoonpanich, P; Rohrer, JD; (2014) Delayed auditory feedback simulates features of nonfluent primary progressive aphasia. J Neurol Sci , 347 (1-2) 345 - 348. 10.1016/j.jns.2014.09.039. Green open access

[thumbnail of 1-s2.0-S0022510X14006376-main.pdf] PDF
1-s2.0-S0022510X14006376-main.pdf

Download (226kB)

Abstract

The pathophysiology of nonfluent primary progressive aphasia (nfvPPA) remains poorly understood. Here, we compared quantitatively speech parameters in patients with nfvPPA versus healthy older individuals under altered auditory feedback, which has been shown to modulate normal speech output. Patients (n=15) and healthy volunteers (n=17) were recorded while reading aloud under delayed auditory feedback [DAF] with latency 0, 50 or 200 ms and under DAF at 200 ms plus 0.5 octave upward pitch shift. DAF in healthy older individuals was associated with reduced speech rate and emergence of speech sound errors, particularly at latency 200 ms. Up to a third of the healthy older group under DAF showed speech slowing and frequency of speech sound errors within the range of the nfvPPA cohort. Our findings suggest that (in addition to any anterior, primary language output disorder) these key features of nfvPPA may reflect distorted speech input signal processing, as simulated by DAF. DAF may constitute a novel candidate pathophysiological model of posterior dorsal cortical language pathway dysfunction in nfvPPA.

Type: Article
Title: Delayed auditory feedback simulates features of nonfluent primary progressive aphasia.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jns.2014.09.039
Publisher version: http://dx.doi.org/10.1016/j.jns.2014.09.039
Language: English
Additional information: © 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Keywords: Altered auditory feedback, Delayed auditory feedback, Dementia, Dorsal pathway, Language, Progressive aphasia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1452434
Downloads since deposit
111Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item