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Identification of clinical target areas in the brainstem of prion-infected mice.

Mirabile, I; Jat, PS; Brandner, S; Collinge, J; (2015) Identification of clinical target areas in the brainstem of prion-infected mice. Neuropathology and Applied Neurobiology , 41 (5) pp. 613-630. 10.1111/nan.12189. Green open access

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Abstract

While prion infection ultimately involves the entire brain, it has long been thought that the abrupt clinical onset and rapid neurological decline in laboratory rodents relates to involvement of specific critical neuroanatomical target areas. The severity and type of clinical signs, together with the rapid progression, suggest the brainstem as a candidate location for such critical areas. In this study we aimed to correlate prion pathology with clinical phenotype in order to identify clinical target areas.

Type: Article
Title: Identification of clinical target areas in the brainstem of prion-infected mice.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/nan.12189
Publisher version: http://dx.doi.org/10.1111/nan.12189
Language: English
Additional information: © 2014 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Brainstem, clinical target areas, cre-lox system, locus coeruleus, neurodegeneration, prions
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Institute of Prion Diseases > MRC Prion Unit at UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1452322
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