Schurich, A;
Henson, SM;
(2014)
The Many Unknowns Concerning the Bioenergetics of Exhaustion and Senescence during Chronic Viral Infection.
Front Immunol
, 5
, Article 468. 10.3389/fimmu.2014.00468.
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Abstract
The immune system cannot be continuously reactivated throughout the lifetime of an organism; there is a finite point at which repeated antigenic challenge leads to the loss of lymphocyte function or the cells themselves. Antigen-specific T cells can be compromised in two ways through the distinct processes of replicative senescence and exhaustion. Senescence is initiated by a DNA damage response whereas exhaustion triggers inhibitory receptors to dampen the immune response. These two distinct pathways not only differ in their initiation but also growing evidence suggests that their biogenergetics is also different. Here, we review recent findings uncovering the metabolism of these unique states.
| Type: | Article |
|---|---|
| Title: | The Many Unknowns Concerning the Bioenergetics of Exhaustion and Senescence during Chronic Viral Infection. |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2014.00468 |
| Publisher version: | http://dx.doi.org/10.3389/fimmu.2014.00468 |
| Language: | English |
| Additional information: | PMCID: PMC4174864 Copyright: © 2014 Schurich and Henson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | bioenergetics, chronic viral infection, exhaustion, metabolism, senescence |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1452304 |
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