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Membrane-Spanning DNA Nanopores with Cytotoxic Effect.

Burns, JR; Al-Juffali, N; Janes, SM; Howorka, S; (2014) Membrane-Spanning DNA Nanopores with Cytotoxic Effect. Angew Chem Int Ed Engl , 53 (46) pp. 12466-12470. 10.1002/anie.201405719. Green open access

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Abstract

DNA-based cytotoxic agents: Nanopores composed of folded DNA featuring a hydrophobic belt of ethyl phosphorothioate groups insert into bilayer membranes and kill cancer cells. The mode by which the pores achieve cell killing is elucidated with confocal microscopy.

Type: Article
Title: Membrane-Spanning DNA Nanopores with Cytotoxic Effect.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/anie.201405719
Publisher version: http://dx.doi.org/10.1002/anie.201405719
Language: English
Additional information: © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
Keywords: DNA origami, cancer, cells, nanopores, nucleic acids
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1452141
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