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Patient-centred pharmaceutical design to improve acceptability of medicines: similarities and differences in paediatric and geriatric populations

Liu, F; Ranmal, S; Batchelor, HK; Orlu-Gul, M; Ernest, TB; Thomas, IW; Flanagan, T; (2014) Patient-centred pharmaceutical design to improve acceptability of medicines: similarities and differences in paediatric and geriatric populations. Drugs , 74 (16) 1871 - 1889. 10.1007/s40265-014-0297-2. Green open access

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Abstract

Patient acceptability of a medicinal product is a key aspect in the development and prescribing of medicines. Children and older adults differ in many aspects from the other age subsets of population and require particular considerations in medication acceptability. This review highlights the similarities and differences in these two age groups in relation to factors affecting acceptability of medicines. New and conventional formulations of medicines are considered regarding their appropriateness for use in children and older people. Aspects of a formulation that impact acceptability in these patient groups are discussed, including, for example, taste/smell/viscosity of a liquid and size/shape of a tablet. A better understanding of the acceptability of existing formulations highlights opportunities for the development of new and more acceptable medicines and facilitates safe and effective prescribing for the young and older populations.

Type: Article
Title: Patient-centred pharmaceutical design to improve acceptability of medicines: similarities and differences in paediatric and geriatric populations
Location: New Zealand
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s40265-014-0297-2
Publisher version: http://dx.doi.org/10.1007/s40265-014-0297-2
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. https://creativecommons.org/licenses/by-nc/3.0/
Keywords: Dosage Form, Oropharyngeal Dysphagia, Solid Dosage Form, Sour Taste, Chewable Tablet
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/1451141
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