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Biomarkers in dementia: clinical utility and new directions.

Ahmed, RM; Paterson, RW; Warren, JD; Zetterberg, H; O'Brien, JT; Fox, NC; Halliday, GM; (2014) Biomarkers in dementia: clinical utility and new directions. J Neurol Neurosurg Psychiatry , 85 (12) 1426 - 1434. 10.1136/jnnp-2014-307662. Green open access

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Abstract

Imaging, cerebrospinal fluid (CSF) and blood-based biomarkers have the potential to improve the accuracy by which specific causes of dementia can be diagnosed in vivo, provide insights into the underlying pathophysiology, and may be used as inclusion criteria and outcome measures for clinical trials. While a number of imaging and CSF biomarkers are currently used for each of these purposes, this is an evolving field, with numerous potential biomarkers in varying stages of research and development. We review the currently available biomarkers for the three most common forms of neurodegenerative dementia, and give an overview of research techniques that may in due course make their way into the clinic.

Type: Article
Title: Biomarkers in dementia: clinical utility and new directions.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2014-307662
Publisher version: http://dx.doi.org/10.1136/jnnp-2014-307662
Language: English
Additional information: This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Keywords: ALZHEIMER'S DISEASE, BRAIN MAPPING, COGNITION, DEMENTIA, FRONTAL LOBE, Biological Markers, Brain, Dementia, Functional Neuroimaging, Humans, Neuroimaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1450359
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