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RPTPs in axons, synapses and neurology

Stoker, AW; (2015) RPTPs in axons, synapses and neurology. Seminars in Cell & Developmental Biology , 37 90 - 97. 10.1016/j.semcdb.2014.09.006. Green open access

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Abstract

Receptor-like protein tyrosine phosphatases represent a large protein family related to cell adhesion molecules, with diverse roles throughout neural development in vertebrates and invertebrates. This review focuses on their roles in axon growth, guidance and repair, as well as more recent findings demonstrating their key roles in pre-synaptic and post-synaptic maturation and function. These enzymes have been linked to memory and neuropsychiatric defects in loss-of-function rodent models, highlighting their potential as future drug targets.

Type: Article
Title: RPTPs in axons, synapses and neurology
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.semcdb.2014.09.006
Publisher version: http://dx.doi.org/10.1016/j.semcdb.2014.09.006
Language: English
Additional information: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Axon growth, Axon guidance, Neurology, PTP, Receptor tyrosine phosphatase, Synapse
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1450345
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