Barchitta, M;
Quattrocchi, A;
Maugeri, A;
Agodi, A;
Vinciguerra, M;
(2014)
LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: A systematic review and meta-analysis.
PLoS ONE
, 9
(10)
10.1371/journal.pone.0109478.
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Abstract
Results: A total of 19 unique articles on 6107 samples (2554 from cancer patients and 3553 control samples) were included in the meta-analysis. LINE-1 methylation levels were significantly lower in cancer patients than in controls (MD: -6.40, 95% CI: - 7.71, - 5.09; p<0.001). The significant difference in methylation levels was confirmed in tissue samples (MD - 7.55; 95% CI: - 9.14, - 65.95; p<0.001), but not in blood samples (MD: - 0.26, 95% CI: - 0.69, 0.17; p=0.23). LINE-1 methylation levels were significantly lower in colorectal and gastric cancer patients than in controls (MD: -8.33; 95% CI: -10.56, -6.10; p< 0.001 and MD: -5.75; 95% CI: -7.75, -3.74; p<0.001) whereas, no significant difference was observed for hepatocellular cancer.
| Type: | Article |
|---|---|
| Title: | LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: A systematic review and meta-analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pone.0109478 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pone.0109478 |
| Language: | English |
| Additional information: | © 2014 Barchitta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1450160 |
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