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LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: A systematic review and meta-analysis

Barchitta, M; Quattrocchi, A; Maugeri, A; Agodi, A; Vinciguerra, M; (2014) LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: A systematic review and meta-analysis. PLoS ONE , 9 (10) 10.1371/journal.pone.0109478. Green open access

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Abstract

Results: A total of 19 unique articles on 6107 samples (2554 from cancer patients and 3553 control samples) were included in the meta-analysis. LINE-1 methylation levels were significantly lower in cancer patients than in controls (MD: -6.40, 95% CI: - 7.71, - 5.09; p<0.001). The significant difference in methylation levels was confirmed in tissue samples (MD - 7.55; 95% CI: - 9.14, - 65.95; p<0.001), but not in blood samples (MD: - 0.26, 95% CI: - 0.69, 0.17; p=0.23). LINE-1 methylation levels were significantly lower in colorectal and gastric cancer patients than in controls (MD: -8.33; 95% CI: -10.56, -6.10; p< 0.001 and MD: -5.75; 95% CI: -7.75, -3.74; p<0.001) whereas, no significant difference was observed for hepatocellular cancer.

Type: Article
Title: LINE-1 hypomethylation in blood and tissue samples as an epigenetic marker for cancer risk: A systematic review and meta-analysis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0109478
Publisher version: http://dx.doi.org/10.1371/journal.pone.0109478
Language: English
Additional information: © 2014 Barchitta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1450160
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