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Multi-modal measurement of the myelin-to-axon diameter g-ratio in preterm-born neonates and adult controls

Melbourne, A; Eaton-Rosen, Z; De Vita, E; Bainbridge, A; Cardoso, MJ; Price, D; Cady, E; ... Ourselin, S; + view all (2014) Multi-modal measurement of the myelin-to-axon diameter g-ratio in preterm-born neonates and adult controls. In: Golland, P and Hata, N and Barillot, C and Hornegger, J and Howe, R, (eds.) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2014: 17th International Conference, Boston, MA, USA, September 14-18, 2014, Proceedings, Part II. (pp. pp. 268-275). Springer International Publishing: Switzerland. Green open access

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Abstract

Infants born prematurely are at increased risk of adverse functional outcome. The measurement of white matter tissue composition and structure can help predict functional performance and this motivates the search for new multi-modal imaging biomarkers. In this work we develop a novel combined biomarker from diffusion MRI and multi-component T2 relaxation measurements in a group of infants born very preterm and scanned between 30 and 40 weeks equivalent gestational age. We also investigate this biomarker on a group of seven adult controls, using a multi-modal joint model-fitting strategy. The proposed emergent biomarker is tentatively related to axonal energetic efficiency (in terms of axonal membrane charge storage) and conduction velocity and is thus linked to the tissue electrical properties, giving it a good theoretical justification as a predictive measurement of functional outcome.

Type: Proceedings paper
Title: Multi-modal measurement of the myelin-to-axon diameter g-ratio in preterm-born neonates and adult controls
Event: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2014
Location: Germany
ISBN-13: 9783319104690
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-319-10470-6_34
Publisher version: http://dx.doi.org/10.1007/978-3-319-10470-6_34
Language: English
Additional information: The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-10470-6_34.
Keywords: Adult, Axons, Brain, Diffusion Tensor Imaging, Female, Humans, Image Interpretation, Computer-Assisted, Infant, Extremely Premature, Infant, Newborn, Male, Middle Aged, Multimodal Imaging, Myelin Sheath, Reproducibility of Results, Sensitivity and Specificity, Young Adult
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Neonatology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1449378
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