Melbourne, A;
Eaton-Rosen, Z;
De Vita, E;
Bainbridge, A;
Cardoso, MJ;
Price, D;
Cady, E;
... Ourselin, S; + view all
(2014)
Multi-modal measurement of the myelin-to-axon diameter g-ratio in preterm-born neonates and adult controls.
In: Golland, P and Hata, N and Barillot, C and Hornegger, J and Howe, R, (eds.)
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2014: 17th International Conference, Boston, MA, USA, September 14-18, 2014, Proceedings, Part II.
(pp. pp. 268-275).
Springer International Publishing: Switzerland.
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Abstract
Infants born prematurely are at increased risk of adverse functional outcome. The measurement of white matter tissue composition and structure can help predict functional performance and this motivates the search for new multi-modal imaging biomarkers. In this work we develop a novel combined biomarker from diffusion MRI and multi-component T2 relaxation measurements in a group of infants born very preterm and scanned between 30 and 40 weeks equivalent gestational age. We also investigate this biomarker on a group of seven adult controls, using a multi-modal joint model-fitting strategy. The proposed emergent biomarker is tentatively related to axonal energetic efficiency (in terms of axonal membrane charge storage) and conduction velocity and is thus linked to the tissue electrical properties, giving it a good theoretical justification as a predictive measurement of functional outcome.
| Type: | Proceedings paper |
|---|---|
| Title: | Multi-modal measurement of the myelin-to-axon diameter g-ratio in preterm-born neonates and adult controls |
| Event: | Medical Image Computing and Computer-Assisted Intervention – MICCAI 2014 |
| Location: | Germany |
| ISBN-13: | 9783319104690 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-319-10470-6_34 |
| Publisher version: | http://dx.doi.org/10.1007/978-3-319-10470-6_34 |
| Language: | English |
| Additional information: | The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-10470-6_34. |
| Keywords: | Adult, Axons, Brain, Diffusion Tensor Imaging, Female, Humans, Image Interpretation, Computer-Assisted, Infant, Extremely Premature, Infant, Newborn, Male, Middle Aged, Multimodal Imaging, Myelin Sheath, Reproducibility of Results, Sensitivity and Specificity, Young Adult |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1449378 |
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