Swerdlow, DI;
Preiss, D;
Kuchenbaecker, KB;
Holmes, MV;
Engmann, JE;
Shah, T;
Sofat, R;
... Sattar, N; + view all
(2014)
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Lancet
, 385
(9965)
pp. 351-361.
10.1016/S0140-6736(14)61183-1.
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PIIS0140673614611831.pdf Download (779kB) |
Abstract
Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the intended drug target.
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