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Auditory evoked fields measured non-invasively with small-animal MEG reveal rapid repetition suppression in the guinea pig

Christianson, GB; Chait, M; De Cheveigné, A; Linden, JF; (2014) Auditory evoked fields measured non-invasively with small-animal MEG reveal rapid repetition suppression in the guinea pig. Journal of Neurophysiology , 112 (12) pp. 3053-3065. 10.1152/jn.00189.2014. Green open access

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Abstract

In animal models, single-neuron response properties such as stimulus-specific adaptation (SSA) have been described as possible precursors to the mismatch negativity (MMN), a human brain response to stimulus change. Here, we attempt to bridge the gap between human and animal studies by characterising responses to changes in the frequency of repeated tone series in the anaesthetised guinea pig using small-animal magnetoencephalography (MEG). We show that: (1) auditory evoked fields (AEFs) qualitatively similar to those observed in human MEG studies can be detected non-invasively in rodents using small-animal MEG; (2) guinea-pig AEF amplitudes reduce rapidly with tone repetition, and this AEF reduction is largely complete by the second tone in a repeated series; and (3) differences between responses to the first (deviant) and later (standard) tones after a frequency transition resemble those previously observed in awake humans using a similar stimulus paradigm.

Type: Article
Title: Auditory evoked fields measured non-invasively with small-animal MEG reveal rapid repetition suppression in the guinea pig
Open access status: An open access version is available from UCL Discovery
DOI: 10.1152/jn.00189.2014
Publisher version: http://dx.doi.org/10.1152/jn.00189.2014
Language: English
Additional information: Copyright © 2014 the American Physiological Society. Licensed under Creative Commons Attribution CC-BY 3.0: © the American Physiological Society.
Keywords: adaptation, guinea pig, magnetoencephalography, repetition suppression, roving standard
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/1448830
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