Hervault, A;
Thanh, NT;
(2014)
Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer.
Nanoscale
, 6
(20)
pp. 11553-11573.
10.1039/c4nr03482a.
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Abstract
Magnetic nanoparticles have been widely investigated for their great potential as mediators of heat for localised hyperthermia therapy. Nanocarriers have also attracted increasing attention due to the possibility of delivering drugs at specific locations, therefore limiting systematic effects. The enhancement of the anti-cancer effect of chemotherapy with application of concurrent hyperthermia was noticed more than thirty years ago. However, combining magnetic nanoparticles with molecules of drugs in the same nanoformulation has only recently emerged as a promising tool for the application of hyperthermia with combined chemotherapy in the treatment of cancer. The main feature of this review is to present the recent advances in the development of multifunctional therapeutic nanosystems incorporating both magnetic nanoparticles and drugs, and their superior efficacy in treating cancer compared to either hyperthermia or chemotherapy as standalone therapies. The principle of magnetic fluid hyperthermia is also presented.
| Type: | Article |
|---|---|
| Title: | Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c4nr03482a |
| Publisher version: | http://dx.doi.org/10.1039/c4nr03482a |
| Language: | English |
| Additional information: | This journal is © The Royal Society of Chemistry 2014. This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence |
| Keywords: | Antineoplastic Agents, Cell Survival, Colloids, Combined Modality Therapy, Contrast Media, Drug Delivery Systems, HeLa Cells, Humans, Hyperthermia, Induced, Liposomes, MCF-7 Cells, Magnetics, Magnetite Nanoparticles, Micelles, Nanomedicine, Neoplasms, Polymers, Water |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1448057 |
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