Maestrini, V;
Treibel, TA;
White, SK;
Fontana, M;
Moon, JC;
(2014)
T1 Mapping for Characterization of Intracellular and Extracellular Myocardial Diseases in Heart Failure.
Curr Cardiovasc Imaging Rep
, 7
, Article 9287. 10.1007/s12410-014-9287-8.
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Abstract
Heart failure (HF) is a major and growing cause of morbidity and mortality. Despite initial successes, there have been few recent therapeutic advances. A better understanding of HF pathophysiology is needed with renewed focus on the myocardium itself. A new imaging technique is now available that holds promise. T1 mapping is a cardiovascular magnetic resonance (CMR) technique for non-invasive myocardial tissue characterization. T1 alters with disease. Pre-contrast (native) T1 changes with a number of processes such as fibrosis, edema and infiltrations. If a post contrast scan is also done, the extracellular volume fraction (ECV) can be measured, a direct measure of the interstitium and its reciprocal, the cell volume. This dichotomy is fundamental - and now measurable promising more targeted therapy and new insights into disease biology.
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