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Tissue-engineered lymphatic graft for the treatment of lymphedema

Kanapathy, M; Patel, NM; Kalaskar, DM; Mosahebi, A; Mehrara, BJ; Seifalian, AM; (2014) Tissue-engineered lymphatic graft for the treatment of lymphedema. Journal of Surgical Research , 192 (2) pp. 544-554. 10.1016/j.jss.2014.07.059. Green open access

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Abstract

BACKGROUND: Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft. METHODS: Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed. RESULTS: The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft. CONCLUSIONS: With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.

Type: Article
Title: Tissue-engineered lymphatic graft for the treatment of lymphedema
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jss.2014.07.059
Publisher version: https://doi.org/10.1016/j.jss.2014.07.059
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Lymphatic graft, Lymphatic regeneration, Lymphedema, Nanotechnology, Tissue engineering, Humans, Lymphatic Vessels, Lymphedema, Nanotechnology, Regeneration, Tissue Engineering
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1447219
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