Chakravarthy, A;
Henderson, S;
Fenton, T;
(2014)
When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer.
Molecular & Cellular Oncology
, 1
(1)
e29914 - e29914.
10.4161/mco.29914.
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Abstract
The APOBEC3 cytidine deaminases play an important role in innate immunity but have also emerged as mediators of somatic mutations in human cancer. We recently reported a high incidence of APOBEC-mediated driver mutations in human papillomavirus-associated cancer, suggesting a key role for these enzymes in the development of such tumors.
| Type: | Article |
|---|---|
| Title: | When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4161/mco.29914 |
| Publisher version: | http://dx.doi.org/10.4161/mco.29914 |
| Language: | English |
| Additional information: | Copyright © 2014 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
| Keywords: | APOBEC, HPV, PIK3CA, cancer, mutagenesis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1447185 |
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