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When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer

Chakravarthy, A; Henderson, S; Fenton, T; (2014) When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer. Molecular & Cellular Oncology , 1 (1) e29914 - e29914. 10.4161/mco.29914. Green open access

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Abstract

The APOBEC3 cytidine deaminases play an important role in innate immunity but have also emerged as mediators of somatic mutations in human cancer. We recently reported a high incidence of APOBEC-mediated driver mutations in human papillomavirus-associated cancer, suggesting a key role for these enzymes in the development of such tumors.

Type: Article
Title: When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.4161/mco.29914
Publisher version: http://dx.doi.org/10.4161/mco.29914
Language: English
Additional information: Copyright © 2014 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
Keywords: APOBEC, HPV, PIK3CA, cancer, mutagenesis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: https://discovery.ucl.ac.uk/id/eprint/1447185
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