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Opioids, decision-making and sex: A cross-over trail of the abuse-related effects of oxycodone and morphine

Phillips, C; (2006) Opioids, decision-making and sex: A cross-over trail of the abuse-related effects of oxycodone and morphine. Doctoral thesis , UCL (University College London). Green open access

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Abstract

In the following paper I aim to provide a review of the literature relevant to this research topic. I begin with a summary of prescription opioids and their use in treatment for pain. I follow with a discussion about opioid misuse and abuse and recent epidemiological research. I review current knowledge about addiction and drug dependency, including recent psychological theories and models of addiction. I also provide an examination of studies which have investigated cognitive impairments associated with drug use, with particular emphasis on deficits in decision-making. Following this, I consider differences in abuse potential between drugs, particularly in light of recent concerns about increases in oxycodone abuse. I highlight gaps in the literature regarding the acute rewarding properties of opioids in non-drug abusing humans. I conclude the review with a rationale for the present study investigating the acute effects and abuse-liability of oxycodone compared to morphine in non-drug abusing healthy volunteers.

Type: Thesis (Doctoral)
Title: Opioids, decision-making and sex: A cross-over trail of the abuse-related effects of oxycodone and morphine
Identifier: PQ ETD:593427
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Thesis digitised by ProQuest. Third party copyright material has been removed from the ethesis. Images identifying individuals have been redacted or partially redacted to protect their identity.
URI: https://discovery.ucl.ac.uk/id/eprint/1446098
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