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Towards the total synthesis of apo-neocarzinostatin

Callan, N; (2010) Towards the total synthesis of apo-neocarzinostatin. Doctoral thesis , UCL (University College London). Green open access

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Neocarzinostatin is a dienediyne chromo protein antibiotic that is made up of a chromophore and an apoprotein (apo-Neocarzinostatin) in a 1:1 ratio. Neocarzinostatin (NCS) is an antitumor agent isolated from Streptomyces carzinostaticus that has shown the effective treatment against acute leukaemia and certain cancers. The aim of the project was to synthesize apo-Neocarzinostatin and there are currently no reports of it being synthesized. The C-terminal fragment was synthesized and did not require further purification. A 12-mer was synthesized that was not part of Apo-NCS but it showed that thioester fragments can be synthesized and cleaved successfully from the resin. Part of the middle fragment of Apo-NCS w as synthesized but only as far as 30 residues: also only SPPS was shown to be successful.

Type: Thesis (Doctoral)
Title: Towards the total synthesis of apo-neocarzinostatin
Identifier: PQ ETD:593043
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Thesis digitised by ProQuest.
URI: https://discovery.ucl.ac.uk/id/eprint/1445719
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