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Functional studies of calcium enriched titanium surfaces.

Mihoc, R.I.; (2007) Functional studies of calcium enriched titanium surfaces. Doctoral thesis , University of London. Green open access

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There exists a clinical requirement for dental implants which will enhance the speed of achievement of osseointegration, its maintenance, and biological and physical properties. Whilst commercially pure titanium remains the material of choice for implant fabrication, a promising approach to enhancing its performance is the surface incorporation of metallic ions, or alkali modification of titanium. Osteoblast behaviour adjacent to the implant is a key factor in osseointegration and it is known that the response of these cells can be modified by the surface implantation of Ca ions. This process may modify cellular behaviour via a number of physicochemical parameters, three of which were examined in this study using commercially pure titanium, into which Ca ions had been implanted: -topography, calcium ion release, and molecular adsorption. Surface topography can mediate cellular responses and may be modified by ion implantation. Laser profilometry and white light interferometry were used to measure the roughness of cp Ti surfaces implanted with either biologically active Ca or chemically inert Ar, together with the effects of nitric acid treatment, which is routinely used in implant manufacture. Ca-ion implantation may also influence cellular responses via accelerated precipitation of calcium phosphate, providing a surface with a chemical composition more similar to that of bone. This may be at least partially due to ion release from the implanted surface. Ion release into water was therefore investigated using ion chromatography and X-ray photoelectron spectroscopy (XPS). The adsorption of organic molecules (e.g. proteins and peptides) is also important in mediating cellular responses. The effects of Ca-implantation on these processes were investigated using XPS to study the surface adsorption of small model biomolecules (amino acids) from an aqueous solution. Ion implantation had little effect on surface topography, however, the implanted Ca ions were readily released into an aqueous solution and the surfaces became more receptive to the absorption of certain amino acids. It is concluded that Ca ion implantation is a potentially valuable technique for the surface enhancement of titanium dental implants.

Type: Thesis (Doctoral)
Title: Functional studies of calcium enriched titanium surfaces.
Identifier: PQ ETD:592151
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Thesis digitised by Proquest
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1444841
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