Kwok, A.N.P.; (2005) A study on the transcription factor Brn-3b, the cell cycle regulation and the cause of elevated Brn-3b expression in cancers. Doctoral thesis , University of London.

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Abstract

Cyclin D1, a cell cycle regulator, plays an important role in cell cycle progression. As overexpression of cyclin D1 has been observed in various cancers, it has been considered that high level of cyclin D1 may cause uncontrolled cell proliferation and thus give rise to cancer. Interestingly, we showed that a POU transcription factor Brn-3b, which has been shown to contribute to uncontrolled cell growth and cause tumourigenesis when expressed at a high level, correlates to the level of cyclin D1 mRNA-when the level of Brn-3b mRNA increased, the levels of cyclin D1 mRNA increased when the level of Brn-3b mRNA decreased, the level of cyclin D1 mRNA also decreased. Thus, the strong correlation between Brn-3b and cyclin D1 indicates that Brn-3b, at least in part, contributes to uncontrolled proliferation by regulating the gene expression of cyclin D1.

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