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Extrastriate projections in human visual system: Evidence from fMRI-informed tractography

Alvarez, I; Schwarzkopf, DS; Clark, CA; (2015) Extrastriate projections in human visual system: Evidence from fMRI-informed tractography. Brain Structure and Function , 220 (5) pp. 2519-2532. 10.1007/s00429-014-0799-4. Green open access

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Abstract

The human optic radiation (OR) is the main pathway for conveying visual input to occipital cortex, but it is unclear whether it projects beyond primary visual cortex (V1). In this study, we used functional MRI mapping to delineate early visual areas in 30 healthy volunteers and determined the termination area of the OR as reconstructed with diffusion tractography. Direct thalamo-cortical projections to areas V2 and V3 were found in all hemispheres tested, with a distinct anatomical arrangement of superior–inferior fiber placement for dorsal and ventral projections, respectively, and a medio-lateral nesting arrangement for projections to V1, V2 and V3. Finally, segment-specific microstructure was examined, revealing sub-fascicular information. This is to date the first in vivo demonstration of direct extrastriate projections of the OR in humans.

Type: Article
Title: Extrastriate projections in human visual system: Evidence from fMRI-informed tractography
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s00429-014-0799-4
Publisher version: http://dx.doi.org/10.1007/s00429-014-0799-4
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited
Keywords: Optic radiation; Visual pathways; Extrastriate; fMRI; Diffusion tensor imaging; Tractography
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1443363
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