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Neural Correlates of Developmental Speech and Language Disorders: Evidence from Neuroimaging.

Liégeois, F; Mayes, A; Morgan, A; (2014) Neural Correlates of Developmental Speech and Language Disorders: Evidence from Neuroimaging. Curr Dev Disord Rep , 1 (3) 215 - 227. 10.1007/s40474-014-0019-1. Green open access

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Abstract

Disorders of speech and language arise out of a complex interaction of genetic, environmental, and neural factors. Little is understood about the neural bases of these disorders. Here we systematically reviewed neuroimaging findings in Speech disorders (SD) and Language disorders (LD) over the last five years (2008-2013; 10 articles). In participants with SD, structural and functional anomalies in the left supramarginal gyrus suggest a possible deficit in sensory feedback or integration. In LD, cortical and subcortical anomalies were reported in a widespread language network, with little consistency across studies except in the superior temporal gyri. In summary, both functional and structural anomalies are associated with LD and SD, including greater activity and volumes relative to controls. The variability in neuroimaging approach and heterogeneity within and across participant samples restricts our full understanding of the neurobiology of these conditions- reducing the potential for devising novel interventions targeted at the underlying pathology.

Type: Article
Title: Neural Correlates of Developmental Speech and Language Disorders: Evidence from Neuroimaging.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s40474-014-0019-1
Publisher version: http://dx.doi.org/10.1007/s40474-014-0019-1
Additional information: © The Author(s) 2014. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. PMCID: PMC4104164
Keywords: Childhood, Childhood apraxia of speech, Communications disorders, Diffusion-weighted MRI, Functional MRI, Language disorder, MRI, Motor speech disorder, Specific language impairment, Speech delay, Speech disorder, Speech sound errors
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1437772
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