Pillidge, K;
Porter, AJ;
Dudley, JA;
Tsai, YC;
Heal, DJ;
Stanford, SC;
(2014)
The behavioural response of NK1R-/- mice to guanfacine resembles its clinical profile in treatment of ADHD.
Br J Pharmacol
, 171
(20)
pp. 4785-4796.
10.1111/bph.12860.
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Abstract
Mice with functional ablation of substance P-preferring neurokinin-1 receptors (NK1R-/-) display behavioural abnormalities resembling those seen in Attention Deficit Hyperactivity Disorder (ADHD). Here, we investigated whether the ADHD treatment, guanfacine, alleviates the hyperactivity and impulsivity/inattention displayed by NK1R-/- mice in the light/dark exploration box (LDEB) and 5-Choice Serial Reaction-Time Task (5-CSRTT), respectively. Prompted by reports of comorbid anxiety in ADHD, we also investigated the effects of guanfacine on anxiety-like behaviour displayed by NK1R-/- and wildtype mice in the elevated plus-maze (EPM).
| Type: | Article |
|---|---|
| Title: | The behavioural response of NK1R-/- mice to guanfacine resembles its clinical profile in treatment of ADHD. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bph.12860 |
| Publisher version: | http://dx.doi.org/10.1111/bph.12860 |
| Additional information: | © 2014 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1437187 |
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