Pina, MF;
Zhao, M;
Pinto, JF;
Sousa, JJ;
Frampton, CS;
Diaz, V;
Suleiman, O;
... Craig, DQM; + view all
(2014)
An investigation into the dehydration behavior of Paroxetine HCl Form I using a combination of thermal and diffraction methods: the identification and characterization of a new anhydrous form.
Crystal Growth & Design
, 14
(8)
3774 - 3782.
10.1021/cg500150r.
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Abstract
Paroxetine HCl can exist as a nonstoichiometric hydrate (Form II) or as a stoichiometric hemihydrate (Form I); the latter is considered to be the stable form and its structure is well-known. However, little work has been performed to investigate its dehydration behavior; hence, the generation of the anhydrous form via dehydration of Form I was investigated. A combination of thermal (differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA)) and diffraction (variable-temperature X-ray powder diffraction (VT-XRPD)) techniques was used. Dehydrated Form I was prepared using ultradry conditions, and the resulting product was compared to dehydrated Form II. DSC indicated that the two dehydrated forms of Forms I and II had distinct melting points. TGA experiments allowed the calculation of the activation energy for the dehydration of Form I, which varies between 86 and 114 kJ/mol. Pawley refinement of the VT-XRPD data suggested that Form I dehydrates to an isostructural anhydrate, since the unit cell parameters of this new form were very similar to those of Form I with only a smaller volume as a consequence of dehydration. Comparison with dehydrated Form II indicated that these two forms represent different crystal entities; hence, a new anhydrous form of paroxetine HCl has been identified.
| Type: | Article |
|---|---|
| Title: | An investigation into the dehydration behavior of Paroxetine HCl Form I using a combination of thermal and diffraction methods: the identification and characterization of a new anhydrous form |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/cg500150r |
| Publisher version: | http://dx.doi.org/10.1021/cg500150r |
| Language: | English |
| Additional information: | This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1437083 |
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