Hill, DP;
Adams, N;
Bada, M;
Batchelor, C;
Berardini, TZ;
Dietze, H;
Drabkin, HJ;
... Lomax, J; + view all
(2013)
Dovetailing biology and chemistry: integrating the Gene Ontology with the ChEBI chemical ontology.
BMC Genomics
, 14
, Article 513. 10.1186/1471-2164-14-513.
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Abstract
Background The Gene Ontology (GO) facilitates the description of the action of gene products in a biological context. Many GO terms refer to chemical entities that participate in biological processes. To facilitate accurate and consistent systems-wide biological representation, it is necessary to integrate the chemical view of these entities with the biological view of GO functions and processes. We describe a collaborative effort between the GO and the Chemical Entities of Biological Interest (ChEBI) ontology developers to ensure that the representation of chemicals in the GO is both internally consistent and in alignment with the chemical expertise captured in ChEBI. Results We have examined and integrated the ChEBI structural hierarchy into the GO resource through computationally-assisted manual curation of both GO and ChEBI. Our work has resulted in the creation of computable definitions of GO terms that contain fully defined semantic relationships to corresponding chemical terms in ChEBI. Conclusions The set of logical definitions using both the GO and ChEBI has already been used to automate aspects of GO development and has the potential to allow the integration of data across the domains of biology and chemistry. These logical definitions are available as an extended version of the ontology from http://purl.obolibrary.org/obo/go/extensions/go-plus.owl
| Type: | Article |
|---|---|
| Title: | Dovetailing biology and chemistry: integrating the Gene Ontology with the ChEBI chemical ontology |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1471-2164-14-513 |
| Publisher version: | http://dx.doi.org/10.1186/1471-2164-14-513 |
| Language: | English |
| Additional information: | © 2013 Hill et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1436778 |
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