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Biological dosimetry for breast cancer radiotherapy: a comparison of external beam and intraoperative radiotherapy

Woolf, DK; Williams, NR; Bakshi, R; Madani, SY; Eaton, DJ; Fawcitt, S; Pigott, K; ... Keshtgar, M; + view all (2014) Biological dosimetry for breast cancer radiotherapy: a comparison of external beam and intraoperative radiotherapy. Springerplus , 3 , Article 329. 10.1186/2193-1801-3-329. Green open access

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Abstract

External beam radiotherapy (EBRT) is the gold standard adjuvant treatment after breast conserving surgery although a recent phase 3 trial has shown the non-inferiority of intraoperative radiotherapy (IORT). Radiation exposure of the heart and cardiac vessels causes an increase in morbidity and mortality following EBRT for breast cancer. We have used γ-H2AX foci formation in peripheral blood lymphocytes as a surrogate marker of dose delivered to the heart and great vessels and have assessed the feasibility of using this technique for biological dosimetry.

Type: Article
Title: Biological dosimetry for breast cancer radiotherapy: a comparison of external beam and intraoperative radiotherapy
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/2193-1801-3-329
Publisher version: http://dx.doi.org/10.1186/2193-1801-3-329
Language: English
Additional information: © 2014 Woolf et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. PMCID: PMC4093905
Keywords: Breast cancer, Cardiac toxicity, H2AX, Intraoperative radiotherapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/1436690
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